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2005 Oral Delivery of Proteins and Peptides, Puchun Liu, CRS Annual Meeting Miami, FL, June 18-22, 2005
Drug Delivery Agent Using Mass Spectrometry (LC-MS), Joseph Fotso; Puchun Liu; Karen Brazzillo; Pingwah Tang; Pittcon 2005, Orlando, FL, February 27-March 4, 2005
A Practical Alternative Green Synthetic Pathway to Carbonxides, Pingwah Tang, American Chemical Society & The Green Chemistry Institute, San Diego, CA, March 2005
Oral Insulin: Rationale, Challenges & Prospects, Ehud Arbit, M.D., 2005 Annual B2B Conference, London, March 24, 2005
Oral Delivery of Biopharmaceuticals:
From Bench to Bedside, Isabel Gomez, World Pharmaceutical Congress, Philadelphia, PA, May 24-26, 2005
Batch Documentation, Shingai Majuru, Conference "Active Ingredients Event", Dublin Ireland, June 21-24, 2005
Sublingual Delivery of Human Parathyroid Hormone 1-34 Using a Delivery Agent (DA) in a Dog Model, Jongbin Lee, Nai Fang Wang, Ehud A, Steve Dinh, P Liu, CRS Annual Meeting Miami FL, June 18-22, 2005
Expandable Gastro-Retentive Dosage Forms Incorporating eligenŽ Technology: A Baseline Study, Jun Liao, Puchun Liu, Steve Dinh, CRS Annual Meeting, Miami FL, June 18-22, 2005
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2004
Oral Delivery of Human Growth Hormone in Monkeys Using a Carrier: 4-Week Repeat Dose Toxicokinetics/Pharmacokinetics/ Pharmacodynamics. P. Liu, T. Shepard, and S. Dinh - The 31st CRS Annual Meeting, Honolulu, HI, June 2004
A Phase I, Double-blind, Randomized, Dose Escalating Crossover Study of an Oral Formulation of Human Growth Hormone in Healthy Male Volunteers. S. Dinh, P. Liu, E. Arbit, T. Shepard, and C. Trapnell - The 31st CRS Annual Meeting, Honolulu, HI, June 2004
Synthesis and Physicochemical Characterization of PEGylated Carriers or Oral Delivery of Macromolecular Drugs. E. Barantsevitch, M. Li, P. Liu, and S. Dinh - The 31st CRS Annual Meeting, Honolulu, HI, June 2004
Radio-telemetric Monitoring on Diabetic Induction and Treatment with Oral Insulin in Rats. Jongbin Lee, Frank Mercogliano, Ehud Arbit, Steven Dinh, and Puchun Liu - AAPS 2004 Baltimore, MD. November 8, 2004
Oral Delivery of Insulin From Solid Dosage Forms Utilizing Emisphere’s eligen® Technology. Nikhil Dhoot, Shingai Majuru, Anant Sharma, and Alpana Gupta - AAPS 2004 Baltimore, MD. November 10, 2004
Solid-State Incompatibility of a Hydrated Excipient With Sodium Salt of a Weak Acid. Galina Levchik (Halina Leuchyk), Jamila Harris, and Shingai Majuru - AAPS 2004 Baltimore, MD. November 8, 2004
Development of LC/MS vs. LC/MS/MS Quantitation Methods for a PEGylated Drug Delivery Agent (PEG-DA). Joseph Fotso, Puchun Liu, Karen Brazzillo, Pingwah Tang, and Ming Li - AAPS 2004 Baltimore, MD. November 9, 2004
Oral Bioavailability of Protein and Peptide Drugs. Isabel Gomez-Orellana - IIR Conference Annual Conference on Protein and Peptide Formulation Strategies for Drug Development and Delivery March 29-31, 2004 San Francisco, CA
Oral Delivery of Anti-Obesity Drugs: Physiological Rationale. Isabel Gomez-Orellana and Ehud Arbit - World Obesity Congress & Expo. July 12-13, 2004 Washington, DC
Understanding drug stability and evaluating drug-excipient compability. Shingai Majuru - Barnett International's 4th Annual Pharmaceutical Excipients Conference, Philadelphia, Pa, May 11-12, 2004
Oral Delivery of Proteins. Puchun Liu - Pharmaceutical Education Associates Conference, Princeton, NJ, May 20-21, 2004
Synthesis and physiochemical characterization of PEGylated delivery Agents for oral delivery. Eugene Baransevitch, Ming Li, Puchun Liu, Steve Dinh - CRS Annual Meeting, Honolulu, Hawaii, June 12-16, 2004
Oral administration of PYY3-36: Effect on weight gain and food intake. Huai-zhen Wang, Michael Goldberg, Ehud Arbit, Steven Dinh, and Isabel Gomez-Orellana. - Annual Meeting of the Endocrine Society, New Orleans, LA, June 16-19, 2004
Oral delivery of PYY3-36. Huai-zhen Wang, Nai Fang Wang, Alpana Gupta, Steven Dinh, Ehud Arbit, Michael Goldberg, and Isabel Gomez-Orellana - CRS Annual Meeting, Honolulu, Hawaii, June 12-16, 2004
Mechanism of Oral Absorption of Calcitonin with Emisphere Drug Delivery Agents. Robert Angelo, Dmitry Malkov, Huai-zhen Wang, Heather Tang, Steven Dinh, and Isabel Gomez-Orellana - CRS Annual Meeting, Honolulu, Hawaii, June 12-16, 2004
Oral delivery of recombinant human growth hormone in monkeys using a delivery agent - 4 week repeat dose Toxicokinetics/Pharmacokinetics/Pharmacodynamics. Puchun Liu, Theresa Shepard, Steve Dinh - CRS Annual Meeting, Honolulu, Hawaii, June 12-16, 2004
A Phase I, double-blind, randomized, dose escalating cross over study of an oral formulation of recombinant human growth hormone in healthy male volunteers. Steve Dinh, Puchun Liu, Theresa Shepard, C. Trapnell - CRS Annual Meeting, Honolulu, Hawaii, June 12-16, 2004
Drug Development: Evaluation of drug-excipient compatibility in light of drug stability. Shingai Majuru - FDA Regulatory Science Training Program, Rockville, MD, September 20, 2004.
Poly (ethylene glycol) conjugates as Effective Delivery agents for Peptide/Protein and other macromolecular drugs. Ming Li, Eugene Barantsevitch, Steve Dinh, Naifang Wang, Jongbin Lee, Puchun Liu - ACS National Meeting, Philadelphia, PA, August 22 - 25, 2004
Advances in Oral Delivery: Insulin as a Model for Oral Delivery of Polypeptides. Ehud Arbit - Annual Meeting of the European Association for the study of Diabetes, Munich, Germany, September 5, 2004
Oral Protein Delivery with the eligen® technology. Isabel Gomez-Orellana - IBC's 4th Annual Delivery Strategies and Peptides, Boston, MA, October 4-6, 2004
Oral Delivery of Insulin. Puchun Liu - 8th Beijing Biotech & Pharma Forum, Beijing, China, September 16-18, 2004
Unique delivery technology for oral drug development. Gabriela Mustata, Steve Dinh - Drug Delivery Global Summit London U.K., October 6-7, 2004
Oral Insulin: More than simply eliminating injection. Michael Goldberg - SMI Diabetes Conference, London, UK, October 18, 2004
Oral Insulin: An Industrial Perspective. Shingai Majuru - Colorcon sponsored Modified Release forum, East Noritton, PA, April 21-22, 2004
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2003
Oral Delivery of New Cromolyn Prodrugs with an Emisphere Delivery Agent. Ming Li, Puchun Liu, and Eugene Barantsevitch. AAPS 2003
A Delayed Release Prototype for Oral Drug Delivery Using EMISPHERE Delivery Agent. Nai Fang Wang, Ming Li, Steven Dinh, and Puchun Liu. AAPS 2003
Oral Delivery of Glucagon Like Peptide-1 and a GLP-1 Analog in Rats. Amy Adams, Kaela Porter, Alpana Gupta, and Viven Wong. AAPS 2003
Oral Delivery of Peptide YY3-36: Initial Feasibility Assessment in Rodents. Jean Wang, Isabel Gomez-Orellana, Michael Goldberg, Ehud Arbit, and Steven Dinh. ADA 2003
Oral Protein Absorption - Mechanistic Studies Using Intestinal Epithelial Cells. Dmitry Malkov, Huai-zhen Wang, Robert Angelo, Heather Tang, Steven Dinh, and Isabel Gomez-Orellana. CRS 2003
The Utility of Emisphere's eligen® Technology for the Oral Delivery of Heparin from Solid Dosage Forms. Shingai Majuru, Kiomar Karami, Syed Ahmed, Anant Sharma, Puchun Liu, Godfreid Owusu-Ababio, Rich Connor, Elliot Bay, Lewis Bender, Jimmy Joseph, and Vivien Wong. AAPS 2003
Rectal Delivery of Recombinant Human Growth Hormone with Emisphere's Delivery Agent: Feasibility Assessment. Nai Fang Wang, Eugene Barantsevitch, Steven Dinh, and Puchun Liu. AAPS 2003
Oral Delivery of Insulin: In Situ Portal Perfusion in a Rat Model. Puchun Liu, Hua Zhang, Jongbin Lee, and Steven Dinh. AAPS 2003
Safety of Orally Administered Insulin/4CNAB at Bedtime. Miriam Kidron, Michael Goldberg, Steven Dinh, Ehud Arbit, and Hanoch- Bar-On. ADA 2003
Pharmacodynamic and Pharmacokinetic of an Oral Insulin Assessed in Type II Diabetes Patients by the Glucose Clamp Technique. Ehud Arbit, Christoph Kapitza, Michael Goldberg, Steven Dinh, Lutz Heinemann, and Tim Heise. CRS 2003
Oral Delivery of Recombinant Human Growth Hormone in Primates: Aqueous Solution and Powder-in-Capsule Formulations. Puchun Liu, M. Amin Khan, Steve Dinh. 30th CRS Annual Meeting 2003
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2002
In Vitro Permeation of Cromolyn Across Excised Rat GI Tissues. Pamela Lai, Puchan Liu and Steven Dinh. AAPS 2002
Preclinical Tolerability Monitoring of 2-[4-(2-Hydroxy-Benzoylamino)Phenyl]Propionic Acid Using Telemetry. Jongbin Lee, Ehud Arbit, John Maher, Steven Dinh and Puchun Liu. The 2nd Annual Meeting of Safety Pharmacology Society, Philadelphia, September 2002
Correlation Between the Apparent Permeability Coefficients of Linear Fatty Acids Across Caco-2 Cell Monolayers and the Induced intra-cellular pH Changes. Earvin Liang, Puchun Liu, and Steven Dinh. ACS National Meeting, Boston, August 2002
Effect of Sodium N-[8-(2-hydroxybenzoyl)amino]Caprylate (SNAC) Concentration and Exposure Time on the Transport of Marker Molecules Across Caco-2 cell Monolayers. Earvin Liang, Puchun Liu, Steven Dinh. Biotechnology Conference, San Diego CA, June 2002
PEG Conjugates- Potent Delivery Agents for Colon Specific Absorption of Protein Drugs. Eugene Barantsevitch, Nai Fang Wang, Richard Conticello and John Smart. 29th CRS Annual Meeting, Seoul Korea, July 2002
Method Development for the Determination of Water in Heparin Sodium. Jamila Baly Harris, Satej Bhandarkar, Rajesh Agarwal, and Robert A. Baughman, Jr. AAPS Annual Meeting, Toronto Canada, November 2002
Evaluation of the Effect of Three Different Oral Heparin/SNAC Formulations on the Pharmacokinetics (PK) of Heparin Following Oral Administration in Healthy Subjects. Richat Abbas, Rajesh Agarwal, Terry Rivera-Schaub, Andrea Leone-Bay, Kiran Chaudhary, and Robert A. Baughman, Jr. AAPS Annual Meeting, Toronto Canada, October 2002
Utility of a Novel Oral Delivery Agent in Promoting Heparin Absorption Across Different Sites of Rats Gastrointestinal Tissues. G. Owusu-Ababio, Kiomars Karami, John Maher, Suraj Kalbag, Don Sarubbi, Puchun Liu, Steven Dinh. AAPS Annual Meeting, Toronto Canada, October 2002
Oral Delivery of Recombinant Human Growth Hormone (rhGH). Puchun Liu, Suraj Kalbag, John Maher, Donald Sarubbi, and Steven Dinh. Proceedings of 29th Annual Meeting of the CRS in Collaboration with the Korean Society for Bio-Materials. Seoul Korea, July 2002
Evaluation of rhGH Bioactivity with a Growth Assay After Oral Dosing of rhGH in Hypophysectiomized Rats. John Maher, H. Havel, Don Sarubbi, Frank Mercogliano, Puchun Liu, Steven Dinh. AAPS Annual Meeting, Toronto Canada, October 2002
Monitoring the Effects of Repeated Blood Sampling on ECG, Body Temperature, and Blood Pressure Using Telemetry Devices. Frank Mercogliano, Jongbin Lee, and John Maher: The 53rd AALAS Meeting (St. Antonio, TX/USA), October 2002
The Effects of Cage Population on the Weight Gain and Food Consumption of Male Sprague-Dawley Rats Housed on Wired Cages. Juanita Thomas, Robert Mahoney, Frank Mercogliano, Monica Tai, Kathryn Ang, Chris Terrasi, John Maher. AALAS 2002
Oral Insulin Absorption with EMISPHERE® Drug Delivery Agents. Mechanistic Studies Using Intestinal Epithelial Cells. Robert Angelo, Dmitry Malkov, Heather Tang, Huai-zhen Wang, Elizabeth Flanders, Steven Dinh, and Isabel Gomez-Orellana. 2nd Annual Diabetes Technology Meeting, November 2002
Oral Delivery of Cromolyn: Bioavailability and Bioactivity after Oral Administration in Animal Models. Don Sarubbi, Puchun Liu, Ehud Arbit, William Abraham, and Steven Dinh. AAAAI 2002
Oral Cromolyn: PK of Cromolyn Sodium Delivery Orally in Healthy Volunteers. Richat Abbas, Robert A. Baughman, Jr, S. DeBruyn, Donald Sarubbi, and Ehud Arbit. EAACI 2002
Oral Insulin: PK & PD of Human Insulin Following Oral Administration of an Insulin/Delivery Agent Capsule in Healthy Volunteers. Richat Abbas, Rajesh Agarwal, Andrea Leone-Bay, Shingai Majuru, Paul Rolan, Cyril Clarke, Colin Scott, Ehud Arbit, and Robert A. Baughman. ADA 2002
Mechanism of Oral Absorption of Insulin with Emisphere Drug Delivery Agents. Dmitry Malkov, Huai-zhen Wang, Robert Angelo, Heather Tang, Steven Dinh, and Isabel Gomez-Orellana. CRS 2002
Gastric Absorption of Oral Insulin in Rats. Donald Sarubbi, John Maher, Puchun Liu, Steven Dinh, and Vivian Wong. AAPS 2002
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2001
Characteristics of the Interaction Between Cromolyn and the Delivery Agents That Facilitate it's Oral Absorption. Huai-zhen Wang, Beth Flanders, Dalton Guo, Steven Dinh and Isabel Gomez-Orellana. AAPS 2001
Use of a pH-Sensitive Probe to Measure the Intra-cellular pH of CACO-2 Cells. Earvin Liang, Puchun Liu, and Steven Dinh. AAPS 2001
Preclinical Tolerability Monitoring Using Telemetry of the Oral Delivery Agent, N-[8-2-Hydroxybenzoyl)Amino]Caprylate(SNAC). Jongbin Lee, Ehud Arbit, John Maher, Steven Dinh, and Puchun Liu. 2001 Safety Pharmacology Society Annual Meeting, Chicago, November 2001
Clinical Pharmaco-Kinetic & Pharmaco-Dynamic Interactions Studies to Evaluate Effects of Antacids Cimetidine and Maalox Pre-treatment on the Absorption of Heparin and it's Delivery Agent SNAC Following Oral Administration in Healthy Subjects. ASH Annual Meeting 2001
Phase-I Study to Assess the Safety and Tolerability of an Oral Heparin Tablet. ASH Annual Meeting 2001
Effect of Excipient Concentration on the Physical and Mechanical Properties of the Oral Heparin Delivery Agent SNAC. Anant N. Sharma, Shingai Majuru, Satej Bhandarkar, Rajesh Agarwal and Robert A. Baughman, Jr. AAPS 2001
A Reversed-Phase High-Performance Liquid Chromatographic Method for the Separation and Quantification of Human Insulin in an Insulin Oral Solid Dosage Preparation. Ehab Ibrahim, Thomas K. Chambers, Rajesh K. Agarwal, Robert A. Baughman, Jr., Keisha E. Robinson and Weifeng Ji. AAPS 2001
Oral Human Insulin Variability In Vivo Rat Studies Resolved by the Use of Dynamic Light Scattering. Jeff Speck, Frank Mercogliano, Jimmy Joseph, and Bruce Variano Jr AAPS 2001
Mechanism of Oral Delivery of Heparin with EMISPHERE® Delivery Agents. Dmitry Malkov, Huai-zhen Wang, Earvin Liang, Steven Dinh and Isabel Gomez-Orellana AAPS 2001
Oral Delivery of Insulin Utilizing Emisphere Delivery Technology as Solid Oral Dosage Form. Steve Malayev, Shingai Majuru, Syed Ahmed, Rajesh Agarwal and Robert A. Baughman, Jr. AAPS 2001
Gastric Absorption of Oral Insulin in Rats. Don Sarubbi, John Maher, Puchan Liu, Steven Dinh, and Vivien Wong. AAPS Annual Meeting, Toronto Canada, November 2002
Bioavailability and Bioactivity of Type-1 Interferon After Oral Administration in Rats. Donald Sarubbi, John Maher, Catherina O'Shaughnessy, Puchun Liu, and Steven Dinh AAPS 2001
A Simplified Bioassay for Analyzing Heparin Potency in Heparin Bulk Drug Substance and Oral Drug Product. Kiran Chaudhary, Yin Liu, Jennifer Faircloth, Rajesh Agarwal and Robert A. Baughman, Jr. AAPS 2001
An In Vitro Evaluation of the Interaction of SNAC with Human CYP450 Isoenzymes. Catherina M. O'Shaughnessy, Lorraine M. Rusch, Richat Abbas, Harry Leopold, Liangfu Chen, Robert A. Baughman, Jr. AAPS 2001
Oral delivery of insulin utilizing EMISPHERE® delivery technology as solid oral dosage form. Vyacheslav Malayev, Shingai Majuru, Syed Ahmed, Rajesh Agarwal, Robert A. Baughman, Jr. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
An open-label, dose escalation study to assess the safety, tolerability, and pharmacokinetics of SNAD, an oral heparin delivery agent, when administered orally as SNAD tablets or heparin/SNAD tablets to healthy male volunteers. Richat Abbas, Andrea Leone-Bay,Terry Rivera-Schaub, Shingai Majuru, James C. Kisicki, 1Robert A. Baughman. 1MDS Pharma Services, Lincoln, NE, USA. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
Bioavailability and bioactivity of type I interferon after oral administration in rats. Donald J. Sarubbi, John Maher, Catherina O'Shaughnessy, Puchun Liu, Steve Dinh AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
Use of a pH-sensitive probe to measure the intracellular pH of Caco-2 cells. Earvin Liang, Puchun Liu, Steve Dinh AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
A clinical drug-interaction study to evaluate effect of antacid pre-treatment on the absorption of heparin and its delivery agent, SNAC, following oral administration in healthy subjects. Richat Abbas, Gregory Osgood, Terry Rivera-Schaub, James C. Kisicki,1Robert A. Baughman 1MDS Pharma Services AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
Characteristics of the interaction between cromolyn and the delivery agents that facilitate its oral absorption. Huai-zhen Wang, Beth Flanders, Dalton Guo, Steven Dinh, Isabel Gomez-Orellana AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
Mechanism of oral delivery of heparin with EMISPHERE® delivery agents.Dmitry Malkov, Huai-zhen Wang, Earvin Liang, Steven Dinh, Isabel Gomez-Orellana. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
Effect of excipient concentration on the physical and mechanical properties of the oral heparin delivery agent SNAC. Anant N. Sharma, Satej Bhandarkar, Rajesh Agarwal, Robert Baughman, Shingai Majuru. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
A size-exclusion liquid chromatographic method as an alternative to bioassay for the quantitation of heparin in a solid dosage form. Thomas K. Chambers, Thano Cotsis, Shingai Majuru, Weifeng Ji, Syed Ahmed, Rajesh K. Agarwal, Robert A. Baughman, Jr. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
A simplified bioassay for analyzing heparin potency in heparin bulk drug substance and oral drug product. Kiran Chaudhary, Yin Liu, Jennifer Faircloth, Rajesh K. Agarwal, Robert A. Baughman, Jr. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
A reversed-phase high-performance liquid chromatographic method for the separation and quantitation of human insulin in an insulin oral solid dosage preparation. Ehab Ibrahim, Thomas K. Chambers, Rajesh K. Agarwal, Robert A. Baughman, Jr., Keisha E. Robinson, Weifeng Ji. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
The effect of tablet coating materials on the oral delivery of heparin. Bhavesh Kothari, Anant Sharma, Shingai Majuru, Kiran Chaudhary, Tom Chambers, Rajesh Agarwal, Robert Baughman. AAPSPharmSci Vol. 3, No. 3, pages (2001) ISSN 1522-0893.
Oral delivery of low molecular weight heparin. Catherina O'Shaughnessy, Andrea Leone-Bay, Robert A. Baughman, Jr., Steven M. Dinh. Abstract Papers - Am. Chem. Soc. (2001), 221st PMSE-450.
Preparation of delivery agents for controlled delivery of macromolecular drugs: Role of chelating agents in the boron-mediated amidation of carboxylic acids and amines. Pingwah Tang, Feng Ye. Chemistry Department, Abstract Papers - Am. Chem. Soc. (2001), 221st PMSE-449.
Interspecies Comparison of SNAC and SNAD In Vitro Plasma Protein Binding. Lorraine Rusch, Richat Abbas, Catherina M. O'Shaughnessy, Liangfu Chen and Robert A. Baughman, Jr. ISSX 2001
PK & PD of SNAD/Heparin in Rhesus Monkeys. Richat Abbas, A. Chaouki Zerouala and Robert A. Baughman, Jr. ISSX 2001
Absolute Bio-Availability of SNAD & PK of SNAD/Heparin in Rats. Richat Abbas, Alda Pombo-Gentile, and Robert A. Baughman, Jr. ISSX 2001
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