Emisphere Technologies, Inc.
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our technology - publications / published articles
2005

Response of the Lung to Pulmonary Insulin Dosing in the Rat Model and Effects of Changes in Formulation, T. Cooper Woods, Bin Zhang, Frank Mercogliano, Steven M. Dinh, Diabetes Technology & Therapeutics, Volume 7, Number 3, 2005

2004

Oral Absorption Enhancement of Cromolyn Sodium Through Noncovalent Complexation. Xuan Ding, Parshuram Rath, Robert Angelo, Thomas Stringfellow, Elizabeth Flanders, Steven Dinh, Isabel Gomez-Orellana, and Joseph R. Robinson. Pharmaceutical Research, Vol. 21, pp. 2196-2206 (2004)

Patentability issues of 3D protein structures. Gabriela Mustata, Drug Discovery Today, July 2004

Advances in the oral delivery of heparin from solid dosage forms using Emisphere’s eligen® oral drug delivery technology. Shingai Majuru, Drug Delivery Technology, October 2004

The Physiological rationale for Oral Insulin Administration. Ehud Arbit, Diabetes Technology & Therapeutics, Volume 6, 2004


2003

Oral Delivery of Macromolecules: A Perspective Using the eligen® technology. Brahma N. Singh, and Shingai Majuru. Drug Delivery Technology June 2003

Challenges for the Oral Delivery of Macromolecules. Michael Goldberg, and Isabel Gomez-Orellana. Nature Review April 2003

Oral Heparin Administration with a Novel Delivery Agent (SNAC) in Healthy Volunteers and Patients Undergoing Elective Total Hip Arthroplasty. S.D. Berkowitz, V.J. Marder, G. Kosutic, R.A. Baughman, Jr. Journal of Thrombosis & Haemotosis 2003

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2002

Oral Insulin: Pharmacokinetics and Pharmacodynamics of Human Insulin Following Oral Administration of an Insulin/Delivery Agent Capsule Healthy Volunteers. Richat Abbas, Andrea Leone-Bay, Rajesh Agawal, Shingai Majuru, Paul Rolan, Cyril Clarke, Colin Scott, Ehud Arbit and Robert A. Baughman, Jr. Diabetes, Journal of the American Diabetes Association, June 2002, Volume 51, A48, S. 2.

Bio-Availability and Biological Efficacy of a New Oral Formulation of Salmon Calcitonin in Healthy Volunteers. Journal of Bone Mineral Research, 2002

Oral Cromolyn: Pharmacokinetics of Cromolyn Sodium Delivered Orally in Healthy Volunteers. Richat Abbas, Robert A. Baughman, S. De Bruyn, Donald Sarubbi, and Ehud Arbit. Allergy - European Journal of Allergy and Clinical Immunology, S. 73, Volume 57, 338, 2002

Oral Delivery of Cromolyn: Bioavailability and Bioactivity After Oral Administration in Animal Models. Don Sarubbi, Puchan Liu, Ehud Arbit, William Abraham, Steve Dinh, American Academy of Allergy & Asthma Institute Conference, New York NY, March 2002

Physical Properties of Compounds Promoting Oral Delivery of Macromolecular Drugs. R. Z. Desamero, H. Cheng, S. Cahill, M. Girvin, H. Deng, R. Callender, P. Rath, B. Variano and J.E. Smart. Biopolymers, 2002; 67(1): pp 26-40.

Interactions of Amidated Acids with Heparin. R. Z. Desamero; H. Cheng; S. Cahill; M. Girvin: H. Deng; R. Callender; P. Rath; B. Variano and J.E. Smart. Biopolymers, 2002; 67(1): pp 41-48.

Pathway of Oral Absorption of Heparin with Sodium N-[8-(2-Hydroxybenzoyl)Amino]Caprylate. Dmitry Malkov, Huai-zhen Wang, Steven Dinh, and Isabel Gomez-Orellana. Pharmaceutical Research, Vol. 19, No. 8, pp. 1180-1184 2002

Mechanism of Oral Absorption of Insulin with EMISPHERE® Drug Delivery Agents. Dmitry Malkov, Huai-zhen Wang, Robert Angelo, Heather Tang, Steven Dinh, and Isabel Gomez-Orellana. 29th Annual Meeting of the Controlled Release Society Proceedings p. 679 2002

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2001

Oral delivery of biologically active parathyroid hormone. Andrea Leone-Bay, Masahiko Sato, Duncan Paton,; Ann H. Hunt, Donald Sarubbi, Monica Carozza, James Chou, James McDonough, Robert A. Baughman, Jr. Pharmaceutical Research, (2001), 18(7), 964-970.

In-Vitro Evaluation of I with Human CYP450 Isoenzymes. Catherina M. O’Shaughnessy, Lorraine M. Rusch, Richat Abbas, Liangfu Chen and Robert A. Baughman, Jr. Drug Metabolism Review, Vol. 33, 381, 2001

Interspecies Comparison of SNAC and SNAD in vitro Plasma Protein Binding. Lorraine M. Rusch, Richat Abbas, Catherina M. O’Shaughnessy, Liangfu Chen, and Robert A. Baughman, Jr. Drug Metabolism Review, Vol. 33, 233, 2001

Pharmacokinetics (PK) and Pharmacodynamics (PD) of SNAD/Heparin in Rhesus Monkeys. Richat Abbas, A.Chaouki Zerouala, and Robert A. Baughman, Jr. Drug Metabolism Review, Vol. 33, 400, 2001

Absolute Bioavailability of SNAD and Pharmacokinetics of SNAD/Heparin in Rats. Richat Abbas, Alda Pombo-Gentile, and Robert A. Baughman, Jr. Drug Metabolism Review, Vol. 33, 124, 2001

Facilitation of Pulmonary Insulin Absorption by H-MAP: PK & PD in Rats. Pharmaceutical Research, December 2001

Immediate and Short-Term Cellular and Biochemical Responses to Pulmonary Single Dose Studies of Insulin and H-MAP. Pharmaceutical Research, December 2001

Oral Delivery of Biologically Active Parathyroid Hormone. Pharmaceutical Research, July 2001

Oral Heparin Prevents Neointimal Hyperplasia After Arterial Injury: Inhibitory Potential Depends on Type of Vascular Injury. Circulation, 2001

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