Barriers to Oral Drug Delivery

Emisphere's Eligen^® Technology overcomes several major obstacles to effective oral delivery including:

Degradation

The high acid content and enzymes of the digestive tract can degrade some drugs before they are absorbed into the bloodstream. The Eligen^® Technology stabilizes the drug molecule in a conformation that reduces degradation. Solid dosage forms that do not dissolve in the stomach can be developed to further reduce degradation. The rapid rate of transit through the biological membrane limits degradation from digestive enzymes.

Poor Absorption

Many macromolecules and highly charged compounds are poorly absorbed through biological membranes. Emisphere's delivery agents interact with the drug molecule to create an entity with significant absorption properties.